{"product_id":"9780306478369","title":"I Domains in Integrins","description":"In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.","brand":"Donald Gullberg","offers":[{"title":"Default Title","offer_id":45753689637182,"sku":"9780306478369","price":5061.08,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4357\/7662\/products\/9780306478369_05ef3006-b867-447e-8743-8c5ddd60b5c2.jpg?v=1707239422","url":"https:\/\/exclusivebooks.co.za\/products\/9780306478369","provider":"Exclusive Books Online","version":"1.0","type":"link"}