{"product_id":"9780792379843","title":"Biochemistry and Genetics of Recq-Helicases","description":"Biochemistry And Genetics of RecQ-Helicases provides a  background into the role of helicases in general and RecQ helicases  specifically in DNA repair. Helicases- enzymes which break down  hydrogen bonds between nucleic acid strands in a nucleoside  triphosphate-dependent manner-are ubiquitous in biology, participating  in processes as diverse as replication, repair, recombination,  transcription, and translation. The RecQ-family helicases are a group  of helicases which have important roles in the maintenance of genomic  stability in many organisms. In humans, mutations in three RecQ-family  helicases lead to disease. This book thoroughly examines these  helicases. Mutations in the BLM gene lead to Bloom syndrome, a  disorder characterized by a susceptibility to many types of cancer.  Mutations in the WRN gene cause Werner syndrome, a disease which in  some respects resembles premature aging. Finally, mutations in a newly  characterized RecQ-family member, RECQ4, may lead to the very rare  recessive disorder Rothmund-Thomson syndrome, a condition  characterized by developmental abnormalities and some aging-like  manifestations. This book is intended for any researchers invested in  these particular disorders, or with a general interest in DNA.","brand":"David B. Lombard","offers":[{"title":"Default Title","offer_id":45858037694782,"sku":"9780792379843","price":3006.45,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4357\/7662\/products\/9780792379843.jpg?v=1707327016","url":"https:\/\/exclusivebooks.co.za\/products\/9780792379843","provider":"Exclusive Books Online","version":"1.0","type":"link"}