{"product_id":"9781138034310","title":"Dose-Response Analysis Using R","description":"Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology.In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development.Key Features:  Provides a practical and comprehensive overview of dose-response analysis.   Includes numerous real data examples to illustrate the methodology.   R code is integrated into the text to give guidance on applying the methods.   Written with minimal mathematics to be suitable for practitioners.   Includes code and datasets on the book’s GitHub: https:\/\/github.com\/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.","brand":"Christian Ritz","offers":[{"title":"Default Title","offer_id":47812745232702,"sku":"9781138034310","price":5165.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4357\/7662\/products\/9781138034310.jpg?v=1707413996","url":"https:\/\/exclusivebooks.co.za\/products\/9781138034310","provider":"Exclusive Books Online","version":"1.0","type":"link"}