Contemporary Approaches to Mitigating Antibacterial Drug Resistance

In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace. The book surveys various strategies, from beta-lactamase inhibitors to nanotechnology-based approaches. It spotlights the potential of natural products, algal derivatives, and lantibiotics, offering a glimpse into the diverse arsenal humanity can harness against antibacterial resistance. Computational biology, bibliometric analyses, and even the intersection with the COVID-19 virus are explored, providing a holistic perspective. The urgency of a coordinated global response, as the World Health Organization advocates, reverberates through these pages. As the world grapples with the increasing threat of antibacterial drug resistance, this book is an indispensable guide, offering a roadmap towards a future where these "wonder drugs" remain effective guardians in our fight against infectious diseases.

Ajmer Singh Grewal is working as an Associate Professor at the Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana (India) since Mar. 02, 2021. He had worked as Assistant Professor at the School College of Pharmacy, Chitkara University (Himachal Pradesh) from July 2019 to February 2021 and at Chitkara College of Pharmacy, Chitkara University (Punjab) from March 2017 to June 2019. Before that, he had worked as Assistant Professor at Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa (Haryana, India) from November 2011 to February 2017. He is a dedicated academic professional with experience of 11+ years committed to pharmaceutical education. He had taught B. Pharm., M. Pharm. and Pharm. D. students and supervised 08 M. Pharm. (Pharmaceutical Chemistry) students in the research area of Drug Design and Medicinal Chemistry. He is currently guiding 03 PhD students in the area of Drug Design and Discovery. He had completed PhD in Pharmaceutical Sciences in the subject area of Computational and Medicinal Chemistry on the project entitled “Design, Synthesis and Biological Evaluation of Newer Glucokinase Activators” from I.K. Gujral Punjab Technical University, Jalandhar (Punjab) in 2019. Earlier, He had seasoned Master of Pharmacy in Pharmaceutical Chemistry on the project entitled “Development and Validation of New Analytical Methods for Estimation of Selected Drugs in Bulk & Pharmaceutical Formulations” from the Institute of Pharmacy and Technology, Salipur, Cuttack in 2011. He had qualified for GATE-2009 (87.09 percentile). His present areas of research include rational drug design and medicinal chemistry of matrix metallo-proteinase (MMP2 and MMP9) inhibitors as anticancer agents, antibacterial drug resistance (NDM-1 inhibitors), glucokinase activators as anti-diabetic agents, aldose reductase inhibitors for diabetic complications, PPAR agonists for the treatment of metabolic syndrome, multi-potent anti-Alzheimer’s agents, selective PDE-4 & PDE-7 inhibitors as anti-inflammatory agents and environmental chemistry. He owns to his credit a total of 90 publications in national and international journals of repute, 20 book chapters, 9 books, 6 patents (provisional application), 2 design patents and various poster presentations (15) at several conferences (both national and international). Currently, he is editing 7 books with Nova Science, Elsevier and IGI Global. Ashwani Kumar Dhingra is presently working as Professor (Pharmaceutical Chemistry) at Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India. He is having a total experience of 15+ years in academics and research. He has obtained PhD from I.K. Gujral Punjab Technical University, Jalandhar (India) in pharmaceutical sciences. He is proficient in technical writing skills as well as analysis and interpretation of data. He is having extensive knowledge of functions related to pharma R&D, product development, laboratory operations a