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Rho GTPases
Although initially described as major regulators of cytoskeletal remodeling, Rho GTPases have been implicated in the establishment of polarity, endocytosis, vesicle trafficking, morphogenesis, cytokinesis, transcriptional activation, cell cycle progression, and apoptosis, to mention a few. In addition, Rho GTPases have acquired medical relevance because of their participation in tumorigenesis and metastasis, in cardiovascular conditions, and as targets of infectious agents. The field has broadened even more with the contribution of studies in model organisms (plants, amoebas, fungi, invertebrates), each adding a particular view to the complexity of the family and vastly enriching our perception of these important signaling components. Divided into five convenient sections, Rho GTPase: Methods and Protocols provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts. Additionally, the volume devotes a section to advanced imaging methods and to recently developed high throughput methods, closing with techniques specifically designed for studies in selected non-mammalian model organisms. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rho GTPase: Methods and Protocols provides techniques that are standard for researchers in the field but also includes protocols for those who, being already familiar with some of the techniques, wish to explore additional aspects.
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Rho GTPases
Although initially described as major regulators of cytoskeletal remodeling, Rho GTPases have been implicated in the establishment of polarity, endocytosis, vesicle trafficking, morphogenesis, cytokinesis, transcriptional activation, cell cycle progression, and apoptosis, to mention a few. In addition, Rho GTPases have acquired medical relevance because of their participation in tumorigenesis and metastasis, in cardiovascular conditions, and as targets of infectious agents. The field has broadened even more with the contribution of studies in model organisms (plants, amoebas, fungi, invertebrates), each adding a particular view to the complexity of the family and vastly enriching our perception of these important signaling components. Divided into five convenient sections, Rho GTPase: Methods and Protocols provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts. Additionally, the volume devotes a section to advanced imaging methods and to recently developed high throughput methods, closing with techniques specifically designed for studies in selected non-mammalian model organisms. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rho GTPase: Methods and Protocols provides techniques that are standard for researchers in the field but also includes protocols for those who, being already familiar with some of the techniques, wish to explore additional aspects.
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1840 Rhodes Blood Libel
The Rhodes blood libel of 1840, an outbreak of anti-Jewish violence, was initiated by the island’s governor in collusion with Levantine merchants, who charged the local Jewish community with murdering a Christian boy for ritual purposes. An episode in the shared histories of Ottomans and Jews, it was forgotten by the former and, even if remembered, misunderstood by the latter. The 1840 Rhodes Blood Libel aims to restore the place of this event in Sephardi and Ottoman history. Based on newly discovered Ottoman and Jewish sources it argues that the acquittal of Rhodian Jews is adequately understood only in the context of the Tanzimat and the Sublime Porte’s foreign relations. Contrary to the common view that Ottoman Jews did not experience the impact of the Tanzimat reforms until the mid-1850s, this study shows that their effects were felt as early as 1840. Furthermore, this book offers a window onto life and intercommunal relations in the Eastern Mediterranean during the late Ottoman era.
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Rho Family GTPases
Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted.The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases.The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.
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Rh Rhodium
This voLume describes the buLk metaL rhodium and its aLLoys with arsenic to ruthenium in accordance with the GmeLin system. The first section, pages 1 through 37, covers in detaiL the foLlowing properties of the metal: CrystaLlographic properties; seLt-diffusion; me- chanicaL properties (tensiLe properties, eLastic moduli, hardness, etc. ); thermaL properties (thermaL expansion, vapour pressure, specific heat, thermaL conductivity, etc. ); eLectricaL and magnetic properties (eLectric resistivity, superconductivity, HaLL effect, thermoeLectric force, magnetic susceptibiLity, etc. ); eLectrochemicaL behaviour and chemicaL reactions. A number of subject matters on metaLlic rhodium are aLready contained together with those of other pLatinum group metals in appropriate chapters of "PLatinum" SuppL. VoL. A 1, 1986. These incLude 1) preparation and eLectrodeposition, 2) zone-refining operations, and 3) chemicaL vapour deposition, sputtering, and thermaL evaporation. Likewise, "PLatinum" SuppL. VoL.2, 1989, aL ready contains information on the 1) separa- tion and properties of the Rh isotopes, 2) physicaL properties of the Rh atom and the atomic 2 ions Rh+ and Rh +, 3) the formation of Rh cLusters, and 4) the moLecuLar properties of Rh * 2 The second and major portion of this voLume, pp. 38 to 273, deaLs with the physicaL and chemicaL properties of rhodium aLloys. Phase diagrams of a Large number of binary and muLticomponent systems are treated in detaiL as weLL as the crystaLlographic and other properties of many intermetalLic compounds.
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Die Rhizarthrose
Die degenerative Erkrankung des Daumensattelgelenks, die Rhizarthrose, führt zu einer wesentlichen Einschränkung der Daumenopposition und damit nahezu jeder grob- und feinmotorischen Greiffunktion der Hand. Im Anfangsstadium der Erkrankung stehen wirksame konservative Therapieoptionen und später gelenkerhaltende Eingriffe zur Verfügung. Im fortgeschrittenen Erkrankungsstadium, nach Ausschöpfen der konservativen Therapie und bei entsprechenden Beschwerden können gelenkresezierende Eingriffe indiziert sein. Die Resektionsarthroplastik des Daumensattelgelenks hat sich als Standardeingriff bewährt, da sie zuverlässig und mit einer niedrigen Komplikationsrate zu einer deutlichen Schmerzlinderung und einer hohen Patientenzufriedenheit führt. Die neueste Generation von Endoprothesen für das Daumensattelgelenk zeigt in mittelfristigen Nachuntersuchungen bei geringen Luxations- und Lockerungsraten und den Vorzügen einer schnelleren Rekonvaleszenz, sowie dem Erhalt von Länge und Stabilität des Daumenstrahls sehr gute Ergebnisse in Bezug auf Schmerzlinderung, Beweglichkeit und Kraftentwicklung.
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Rho GTPases
This detailed book expands upon the previous edition with a collection of methods for those performing experimental work on small GTPases of the Rho family. Split into four sections, the volume explores computational modeling and imaging procedures, biochemical methods related to post-translational modifications of Rho GTPases as well as some high throughput methods, functional assays that allow for monitoring the consequences of manipulating Rho GTPases in a variety of cell types and cell biology processes, and techniques specifically designed for studies in selected non-mammalian model organisms (zebrafish, social ameba, plants and algae). Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls. Authoritative and up-to-date, Rho GTPases: Methods and Protocols, Second Edition constitutes an invaluable tool for all those with an interest in this remarkable family of signaling proteins.
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Religious Life in Late Classical and Hellenistic Rhodes
The ancient state of Rhodes was famous for many things in the Hellenistic period; it emerged as an economic powerhouse thanks to its strategic position on maritime trade routes, its status further bolstered by its proud independence in an era of great kings, and its cultural successes and heritage celebrated by contemporaries as well as later writers. But what did this state look like on the inside, and what social and religious forces contributed to its success? This book explores the origins of the Rhodian state in the late fifth century BC, a union born out of three separate city-states, Lindos, Cameiros, and Ialysos. By digging deep into the abundant epigraphic culture that survives, narratives emerge that tell the stories of these Rhodians and their communities. Despite the political unification and the foundation of a famed and successful capital city, Rhodes-town, the three old centres continued to exhibit distinctive and seemingly lively local religious cultures. What these looked like, and the question of whether they indicate cultic vitality rather than ossification, is considered in detail by examining the local pantheons and the religious dynamics and interactions that characterised and shaped them. Pulling together the diverse threads and local customs, a diachronic religious history of Rhodes is sketched. The role religion played in the social landscape of Hellenistic Rhodes is addressed through a thorough examination of priesthoods. Finally, providing a counterbalance to the institutional side of religion, the lived experience of Rhodian religious associations is depicted. The resulting picture offers a nuanced insight into the religious life and history of a Hellenistic city-state.
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