Classification Analysis of DNA Microarrays

Wiley Series in Bioinformatics: Computational Techniques and Engineering Yi Pan and Albert Y. Zomaya, Series Editors Wide coverage of traditional unsupervised and supervised methods and newer contemporary approaches that help researchers handle the rapid growth of classification methods in DNA microarray studies Proliferating classification methods in DNA microarray studies have resulted in a body of information scattered throughout literature, conference proceedings, and elsewhere. This book unites many of these classification methods in a single volume. In addition to traditional statistical methods, it covers newer machine-learning approaches such as fuzzy methods, artificial neural networks, evolutionary-based genetic algorithms, support vector machines, swarm intelligence involving particle swarm optimization, and more. Classification Analysis of DNA Microarrays provides highly detailed pseudo-code and rich, graphical programming features, plus ready-to-run source code. Along with primary methods that include traditional and contemporary classification, it offers supplementary tools and data preparation routines for standardization and fuzzification; dimensional reduction via crisp and fuzzy c-means, PCA, and non-linear manifold learning; and computational linguistics via text analytics and n-gram analysis, recursive feature extraction during ANN, kernel-based methods, ensemble classifier fusion. This powerful new resource: Provides information on the use of classification analysis for DNA microarrays used for large-scale high-throughput transcriptional studiesServes as a historical repository of general use supervised classification methods as well as newer contemporary methodsBrings the reader quickly up to speed on the various classification methods by implementing the programming pseudo-code and source code provided in the bookDescribes implementation methods that help shorten discovery times Classification Analysis of DNA Microarrays is useful for professionals and graduate students in computer science, bioinformatics, biostatistics, systems biology, and many related fields.

LEIF E. PETERSON, PHD, is Associate Professor of Public Health, Weill Cornell Medical College, Cornell University, and is with the Center for Biostatistics, The Methodist Hospital Research Institute (Houston). He is a member of the IEEE Computational Intelligence Society, and Editor-in-Chief of the BioMed Central Source Code for Biology and Medicine.