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Biomarkers of Hip Implant Function

Ilona Swiatkowska
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      Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. The recent worldwide controversy surrounding metal-on-metal bearings – and increasing concern over the use of metallic biomaterials in general – means that advice on how to manage patients with metal implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and the risk of local or systemic toxicity. Biomarkers of Hip Implant Function aims to bring together all established and promising new biomarkers and critically evaluate their clinical usefulness. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and manage their patients. The work may also benefit engineers and joint implant manufacturers by guiding improvements in implant design, and be of interest to regulators and policymakers to inform guidelines on the follow-up of hip implant recipients. 
      Format: CONTRIBUTORS: Ilona Swiatkowska EAN: 9780128215968 COUNTRY: United States PAGES: WEIGHT: 450 g HEIGHT: 229 cm
      PUBLISHED BY: Elsevier Science Publishing Co Inc DATE PUBLISHED: 2023-01-23 CITY: GENRE: SCIENCE / Life Sciences / Biology, SCIENCE / Life Sciences / General WIDTH: 152 cm SPINE:

      Book Themes:

      Surgical orthopaedics and fractures

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      Ilona Swiatkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.
      Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. The recent worldwide controversy surrounding metal-on-metal bearings – and increasing concern over the use of metallic biomaterials in general – means that advice on how to manage patients with metal implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and the risk of local or systemic toxicity. Biomarkers of Hip Implant Function aims to bring together all established and promising new biomarkers and critically evaluate their clinical usefulness. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and manage their patients. The work may also benefit engineers and joint implant manufacturers by guiding improvements in implant design, and be of interest to regulators and policymakers to inform guidelines on the follow-up of hip implant recipients. 
      Format: CONTRIBUTORS: Ilona Swiatkowska EAN: 9780128215968 COUNTRY: United States PAGES: WEIGHT: 450 g HEIGHT: 229 cm
      PUBLISHED BY: Elsevier Science Publishing Co Inc DATE PUBLISHED: 2023-01-23 CITY: GENRE: SCIENCE / Life Sciences / Biology, SCIENCE / Life Sciences / General WIDTH: 152 cm SPINE:

      Book Themes:

      Surgical orthopaedics and fractures

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      Ilona Swiatkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.

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