Non-dopamine Lesions in Parkinson's Disease

Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progressionand treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated.The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted(the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesionsassociated with the most common symptoms found in patients with Parkinson's disease.

It is becoming increasingly clear that the clinically heterogenous presentation of Parkinson's "Disease reflects compromise of both dopaminergic and non-dopaminergic systems...A more complete understanding of Parkinson's Disease mandates an in-depth exploration of the many other compromised neural systems. The contributions edited by Drs. Halliday, Barker, and Rowe have succeeded remarkably---. But more significantly, each chapter provides a cogent and succinct discussion of the relevant basic as well as applied physiology for each compromised system, and can serve as an up-to-date primer of translational clinical neurophysiology for practicing as well as academic Neurologists. This is an outstanding one-of-a-kind book, and a must read." - Stanley H. Appel MD, Peggy and Gary Edwards Distinguished Endowed Chair for the Treatment and Research of ALS, Chair, Dept of Neurology, Methodist Neurological Institute, Houston, TX "This interesting book...focuses upon a range of Parkinson's disease-related symptoms widely believed to have a non-dopaminergic basis. Such symptoms are almost exclusively "non-motor" in nature. It is thus highly topical, as our awareness of non-motor symptoms is increasing, together with the impact such symptoms have on the patient and their families. The book deals with non-motor symptoms in a systematic and in depth way, with a strong emphasis on the neuroanatomical and pathophysiological basis of the symptoms that will be welcomed by those wishing to acquire a more detailed understanding of the problems. The book... will be best appreciated by the reader with extant basic knowledge, aiming to move to a higher level of understanding." - David J Burn, Professor of Movement Disorders Neurology & Honorary Consultant Neurologist, Clinical Ageing Research Unit, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, UK

Glenda M. Halliday, PhD, is a neuroscientist currently working on the pathogenesis of neurodegenerative diseases. Her research has highlighted broader pathological involvement in Parkinson's disease and especially in dementia with Lewy bodies, with recent work suggesting that humoral immunity is involved. Roger A. Barker, PhD did his undergraduate training at the University of Oxford and then St Thomas Hospital in London. For the last 10 years he has been an honorary consultant in Neurology at the Addenbrooke's Hospital in Cambridge as well as being the University Reader in Clinical Neuroscience. He runs a large research group looking at the heterogeneity and natural history of PD as well as a basic science programme of work on the development of novel therapies for PD including stem cell basedtreatments. Dominic B. Rowe, FRACP, PhD, is Professor of Neurology at Macquarrie University in Sydney, Australia as well as a Consultant Neurologist at The University of Sydney. He first studiedbiochemistry and medicine and then completed training in internal medicine and neurology in Sydney before completing neurology training at Queen's Square and Newcastle uponTyne. His doctoral studies on the pathogenesis of Parkinson's disease were performed at Baylor College of Medicine, Texas and completed at the University of New South Wales. He has worked clinically as a neurologist and academic. His research is focused on the mechanisms involved in Parkinson's disease and Motor NeuroneDisease. He is the chairman of the Motor Neurone Disease Research Institute of Australia and is the author of three textbooks and more than 30 original articles.