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Oxidative Stress and Neurodegenerative Disorders

G. Ali Qureshi, S. Hasan Parvez
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      Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.
      Format: CONTRIBUTORS: G. Ali Qureshi, S. Hasan Parvez EAN: 9780444528094 COUNTRY: United Kingdom PAGES: WEIGHT: 1610 g HEIGHT: 240 cm
      PUBLISHED BY: Elsevier Science & Technology DATE PUBLISHED: 2007-03-22 CITY: GENRE: MEDICAL / General, MEDICAL / Geriatrics, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Genetics & Genomics, SCIENCE / Life Sciences / Neuroscience WIDTH: 165 cm SPINE:

      Book Themes:

      Medical diagnosis, Neurosciences

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      Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.
      Format: CONTRIBUTORS: G. Ali Qureshi, S. Hasan Parvez EAN: 9780444528094 COUNTRY: United Kingdom PAGES: WEIGHT: 1610 g HEIGHT: 240 cm
      PUBLISHED BY: Elsevier Science & Technology DATE PUBLISHED: 2007-03-22 CITY: GENRE: MEDICAL / General, MEDICAL / Geriatrics, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Genetics & Genomics, SCIENCE / Life Sciences / Neuroscience WIDTH: 165 cm SPINE:

      Book Themes:

      Medical diagnosis, Neurosciences

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