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Endocrine Manifestations of Systemic Autoimmune Diseases

Ronald Asherson, Sara Walker, Luis J. Jara
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      This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.
      Format: CONTRIBUTORS: Ronald Asherson, Sara Walker, Luis J. Jara EAN: 9780444531728 COUNTRY: United Kingdom PAGES: WEIGHT: 1020 g HEIGHT: 262 cm
      PUBLISHED BY: Elsevier Science & Technology DATE PUBLISHED: 2008-05-12 CITY: GENRE: MEDICAL / General, MEDICAL / Endocrinology & Metabolism, MEDICAL / Immunology, MEDICAL / Pharmacology, MEDICAL / Rheumatology WIDTH: 192 cm SPINE:

      Book Themes:

      Immunology, Endocrinology

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      This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.
      Format: CONTRIBUTORS: Ronald Asherson, Sara Walker, Luis J. Jara EAN: 9780444531728 COUNTRY: United Kingdom PAGES: WEIGHT: 1020 g HEIGHT: 262 cm
      PUBLISHED BY: Elsevier Science & Technology DATE PUBLISHED: 2008-05-12 CITY: GENRE: MEDICAL / General, MEDICAL / Endocrinology & Metabolism, MEDICAL / Immunology, MEDICAL / Pharmacology, MEDICAL / Rheumatology WIDTH: 192 cm SPINE:

      Book Themes:

      Immunology, Endocrinology

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