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DNA Repair of Cancer Stem Cells

Lesley A Mathews
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      The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
      Format: Hardback CONTRIBUTORS: Lesley A Mathews EAN: 9789400745896 COUNTRY: Netherlands PAGES: WEIGHT: 458 g HEIGHT: 235 cm
      PUBLISHED BY: Springer DATE PUBLISHED: 2012-07-27 CITY: GENRE: MEDICAL / General, MEDICAL / Oncology / General, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Life Sciences / Molecular Biology WIDTH: 155 cm SPINE:

      Book Themes:

      Medical research, Oncology, Developmental biology

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      The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
      Format: Hardback CONTRIBUTORS: Lesley A Mathews EAN: 9789400745896 COUNTRY: Netherlands PAGES: WEIGHT: 458 g HEIGHT: 235 cm
      PUBLISHED BY: Springer DATE PUBLISHED: 2012-07-27 CITY: GENRE: MEDICAL / General, MEDICAL / Oncology / General, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Life Sciences / Molecular Biology WIDTH: 155 cm SPINE:

      Book Themes:

      Medical research, Oncology, Developmental biology

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