Personalized and Precision Nanomedicine for Cancer Treatment

This book discusses the role of nanotechnology and nanomaterials in precision and personalized medicine approaches toward cancer diagnosis, treatment, early detection, and efficient drug delivery. It also covers the applications of nanotechnology in tumor chemotherapy through increasing the specificity of anticancer agents, enhancing the killing effect of tumors, and reducing the toxic and side effects. It also discusses the significance of cancer stem cells in the diagnosis and prognosis of cancer and prospects for targeting cancer stem cells for cancer therapies by nanomaterial. Further, a chapter discusses the current status and future perspectives of actively targeted theranostics nanoparticles for tumors and associated challenges. The chapter also reviews the therapeutic role of different species of nanoparticles for enhanced radio sensitization in cancers. The subsequent chapters cover the recent advances in nanotechnology-based chemoprevention strategies for various cancers.Useful aspect of computational tools and methods in Cancer nanomedicine is discussed. This is an ideal book for students, oncologists, and researchers working in allied fields of nanotechnology, cancer, and targeted drug delivery.

Dr. Mohammad Azhar Aziz stands as a beacon of innovation in the realm of cancer research, with a profound commitment to unraveling the mysteries of the disease. Born into a family that valued education and inquiry, Azhar's journey from Lucknow to becoming a leading cancer researcher has been marked by intellectual rigor and an unyielding passion for scientific discovery. His father was a physician and his mother an educationist and homemaker providing an ecosystem where questioning was a norm. Azhar was born and raised in Lucknow, the capital city of Uttar Pradesh, India. He went to Christ Church College for schooling followed by an undergraduate degree (BSc) from Bappa Sri Narain Vocational Degree College, Lucknow University.Azhar's academic odyssey began at Aligarh Muslim University, where he immersed himself in the world of biological science. His thirst for knowledge and a desire to make a tangible impact on human health led him to Biotechnology. Recognizing the potential of biotechnology in transforming the landscape of cancer research, Azhar delved into interdisciplinary studies that melded biology with other disciplines like engineering.Venturing further into his academic pursuits, Azhar honed his skills at the Center for Biotechnology at Jawaharlal Nehru University. Here, under the mentorship of leading experts, he pioneered groundbreaking research at the intersection of Biotechnology and molecular biology. His work led to the development of pioneering work on vaccine development.He went to Case Western Reserve University and The Cleveland Clinic to engage in cutting-edge interdisciplinary work on integrated cancer research. He worked on National Cancer Institute, USA-sponsored projects on systems biology. His work has been instrumental in developing innovative approaches to detect, treat, and understand the intricacies of cancer at the molecular level.Azhar established the spirit of integration at King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. He built a colorectal cancer program by spinning together a team of surgeons, pathologists, computational biologists, and molecular biologists. After working for 16 years abroad, he joined Aligarh Muslim University to serve as director of the Interdisciplinary Nanotechnology Center. His investigations into nano-scale drug delivery systems for targeted cancer therapy opened new avenues for precision medicine, earning him recognition as a trailblazer in the field. He has published several scientific papers in journals of international repute. He is an awardee of Best Researcher, Young Scientist, and several other prominent awards from international institutions and agencies.As a faculty member at the Interdisciplinary Nanotechnology Center, Azhar has continued to drive transformative research initiatives. His leadership has fostered a collaborative environment that brings together scientists, engineers, and medical experts to address the multifaceted challenges of cancer.